Drug interactions
Atomoxetine + Desflurane
Severity: Moderate
Atomoxetine and Desflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics such as desflurane can prolong the QT interval, and atomoxetine may add to this effect during surgery. Atomoxetine can also increase heart rate and blood pressure, which complicates anesthetic hemodynamics.
What this interaction means in plain words
Atomoxetine and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Desflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation, with sympathomimetic effects from atomoxetine.
What to do
Tell the anesthesia team about atomoxetine use before surgery and keep electrolytes normal. Monitor ECG and hemodynamics throughout the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Desflurane
Frequently asked questions
Can I take Atomoxetine with Desflurane?
MediHelp rates the interaction as moderate. Atomoxetine and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics such as desflurane can prolong the QT interval, and atomoxetine may add to this effect during surgery. Atomoxetine can also increase heart rate and blood pressure, which complicates anesthetic hemodynamics.
How serious is the interaction between Atomoxetine and Desflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about atomoxetine use before surgery and keep electrolytes normal. Monitor ECG and hemodynamics throughout the procedure.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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