Drug interactions
Atomoxetine + Eliglustat
Severity: Major
Atomoxetine and Eliglustat: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits CYP2D6, the main enzyme clearing atomoxetine, and so can raise atomoxetine exposure, especially in extensive metabolizers. Both agents may also prolong the QT interval.
What this interaction means in plain words
Atomoxetine and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atomoxetine belongs to Central Nervous System; Eliglustat belongs to Miscellaneous.
Why it happens
CYP2D6 inhibition by eliglustat reduces atomoxetine clearance, with additive QT effects.
What to do
Start atomoxetine at a reduced dose and titrate slowly while monitoring heart rate, blood pressure and ECG. Consider an alternative if QT risk factors are present.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Atomoxetine with Eliglustat?
MediHelp rates the interaction as major. Atomoxetine and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eliglustat inhibits CYP2D6, the main enzyme clearing atomoxetine, and so can raise atomoxetine exposure, especially in extensive metabolizers. Both agents may also prolong the QT interval.
How serious is the interaction between Atomoxetine and Eliglustat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start atomoxetine at a reduced dose and titrate slowly while monitoring heart rate, blood pressure and ECG. Consider an alternative if QT risk factors are present.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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