Drug interactions
Eliglustat + Pimozide
Severity: Contraindicated
Eliglustat and Pimozide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat can prolong the PR, QRS and QT intervals at high concentrations, and pimozide is a potent QT-prolonging drug. Eliglustat is also a CYP2D6 inhibitor and a CYP3A4 substrate, which may further raise pimozide exposure.
What this interaction means in plain words
Eliglustat and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Eliglustat belongs to Miscellaneous; Pimozide belongs to Central Nervous System.
Why it happens
Additive QT prolongation plus CYP2D6 inhibition reducing pimozide clearance.
What to do
Avoid the combination. Choose alternative therapy for either condition.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Posaconazole Contraindicated
Frequently asked questions
Can I take Eliglustat with Pimozide?
MediHelp rates the interaction as contraindicated. Eliglustat and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Eliglustat can prolong the PR, QRS and QT intervals at high concentrations, and pimozide is a potent QT-prolonging drug. Eliglustat is also a CYP2D6 inhibitor and a CYP3A4 substrate, which may further raise pimozide exposure.
How serious is the interaction between Eliglustat and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Choose alternative therapy for either condition.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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