Drug interactions
Atomoxetine + Fluphenazine
Severity: Moderate
Atomoxetine and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine can prolong the QT interval, and atomoxetine may add QT and heart rate effects. Fluphenazine is also a CYP2D6 substrate and inhibitor, which may modestly increase atomoxetine exposure.
What this interaction means in plain words
Atomoxetine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation plus possible CYP2D6 inhibition by fluphenazine.
What to do
Obtain a baseline ECG and monitor electrolytes, heart rate and blood pressure. Consider a lower atomoxetine starting dose and slow titration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Atomoxetine with Fluphenazine?
MediHelp rates the interaction as moderate. Atomoxetine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine can prolong the QT interval, and atomoxetine may add QT and heart rate effects. Fluphenazine is also a CYP2D6 substrate and inhibitor, which may modestly increase atomoxetine exposure.
How serious is the interaction between Atomoxetine and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor electrolytes, heart rate and blood pressure. Consider a lower atomoxetine starting dose and slow titration.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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