Drug interactions
Atomoxetine + Haloperidol
Severity: Moderate
Atomoxetine and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol inhibits CYP2D6 and may raise atomoxetine concentrations, and both drugs may affect the QT interval. Together they can increase the risk of tachycardia, hypertension and ventricular arrhythmia.
What this interaction means in plain words
Atomoxetine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by haloperidol plus additive QT prolongation.
What to do
Obtain a baseline ECG, correct potassium and magnesium, and monitor QTc after dose changes. Start atomoxetine at a reduced dose and titrate slowly while monitoring heart rate and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Atomoxetine with Haloperidol?
MediHelp rates the interaction as moderate. Atomoxetine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol inhibits CYP2D6 and may raise atomoxetine concentrations, and both drugs may affect the QT interval. Together they can increase the risk of tachycardia, hypertension and ventricular arrhythmia.
How serious is the interaction between Atomoxetine and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, correct potassium and magnesium, and monitor QTc after dose changes. Start atomoxetine at a reduced dose and titrate slowly while monitoring heart rate and blood pressure.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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