Drug interactions
Atomoxetine + Iloperidone
Severity: Moderate
Atomoxetine and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is associated with dose-related QT prolongation, and atomoxetine may add to it. Combined use may raise the risk of torsades de pointes, especially in CYP2D6 poor metabolizers or with other risk factors.
What this interaction means in plain words
Atomoxetine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Iloperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation; both drugs are CYP2D6 substrates, so exposure may also rise in poor metabolizers.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes. Avoid in patients with known QT risk factors and consider alternatives if QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Atomoxetine with Iloperidone?
MediHelp rates the interaction as moderate. Atomoxetine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is associated with dose-related QT prolongation, and atomoxetine may add to it. Combined use may raise the risk of torsades de pointes, especially in CYP2D6 poor metabolizers or with other risk factors.
How serious is the interaction between Atomoxetine and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes. Avoid in patients with known QT risk factors and consider alternatives if QTc lengthens.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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