Drug interactions
Atomoxetine + Itraconazole
Severity: Moderate
Atomoxetine and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, so combining them may increase the risk of arrhythmia. Atomoxetine also raises heart rate and blood pressure, which adds to cardiovascular concern.
What this interaction means in plain words
Atomoxetine and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Itraconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation; itraconazole is not a meaningful inhibitor of CYP2D6, the main atomoxetine pathway.
What to do
Check the baseline ECG and electrolytes, especially in patients with cardiac risk factors. Monitor heart rate, blood pressure and QTc during co-therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Itraconazole?
MediHelp rates the interaction as moderate. Atomoxetine and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, so combining them may increase the risk of arrhythmia. Atomoxetine also raises heart rate and blood pressure, which adds to cardiovascular concern.
How serious is the interaction between Atomoxetine and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the baseline ECG and electrolytes, especially in patients with cardiac risk factors. Monitor heart rate, blood pressure and QTc during co-therapy.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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