Drug interactions
Atomoxetine + Loperamide
Severity: Moderate
Atomoxetine and Loperamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may prolong the QT interval, and loperamide overdose is associated with torsades de pointes. Combined use may raise arrhythmia risk, particularly with other risk factors.
What this interaction means in plain words
Atomoxetine and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Loperamide belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation.
What to do
Do not exceed labeled loperamide doses. Monitor ECG and correct potassium and magnesium in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loperamide
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Loperamide?
MediHelp rates the interaction as moderate. Atomoxetine and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs may prolong the QT interval, and loperamide overdose is associated with torsades de pointes. Combined use may raise arrhythmia risk, particularly with other risk factors.
How serious is the interaction between Atomoxetine and Loperamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not exceed labeled loperamide doses. Monitor ECG and correct potassium and magnesium in at-risk patients.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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