Drug interactions
Atomoxetine + Osilodrostat
Severity: Moderate
Atomoxetine and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osilodrostat can prolong the QT interval, and combining it with atomoxetine may add to arrhythmia risk. Osilodrostat also can cause hypokalemia, which increases the danger.
What this interaction means in plain words
Atomoxetine and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Osilodrostat belongs to Endocrine.
Why it happens
Additive QTc prolongation, with hypokalemia as a further risk factor.
What to do
Obtain a baseline ECG and monitor it during treatment, and correct potassium and magnesium. Reassess if QTc lengthens significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Atomoxetine with Osilodrostat?
MediHelp rates the interaction as moderate. Atomoxetine and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osilodrostat can prolong the QT interval, and combining it with atomoxetine may add to arrhythmia risk. Osilodrostat also can cause hypokalemia, which increases the danger.
How serious is the interaction between Atomoxetine and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it during treatment, and correct potassium and magnesium. Reassess if QTc lengthens significantly.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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