Drug interactions
Citalopram + Osilodrostat
Severity: Major
Citalopram and Osilodrostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes. The risk rises with electrolyte disturbances, cardiac disease or higher citalopram doses.
What this interaction means in plain words
Citalopram and Osilodrostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Citalopram belongs to Central Nervous System; Osilodrostat belongs to Endocrine.
Why it happens
Additive prolongation of cardiac repolarization (QT interval).
What to do
Obtain a baseline ECG and repeat after starting or changing doses, and correct potassium and magnesium. Limit citalopram dose or choose a less QT-active antidepressant if the QTc becomes prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Citalopram with Osilodrostat?
MediHelp rates the interaction as major. Citalopram and Osilodrostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes. The risk rises with electrolyte disturbances, cardiac disease or higher citalopram doses.
How serious is the interaction between Citalopram and Osilodrostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat after starting or changing doses, and correct potassium and magnesium. Limit citalopram dose or choose a less QT-active antidepressant if the QTc becomes prolonged.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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