Drug interactions
Amisulpride + Osilodrostat
Severity: Major
Amisulpride and Osilodrostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osilodrostat can prolong the QT interval and its labeling advises caution with other QT-prolonging drugs. Together with amisulpride the risk of torsades de pointes is increased, particularly if hypokalemia develops from cortisol suppression changes.
What this interaction means in plain words
Amisulpride and Osilodrostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Osilodrostat belongs to Endocrine.
Why it happens
Additive QT prolongation; osilodrostat-related hypokalemia may further increase risk.
What to do
Obtain a baseline ECG and monitor it after starting or changing doses. Correct potassium and magnesium, or use an alternative to amisulpride.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Amisulpride with Osilodrostat?
MediHelp rates the interaction as major. Amisulpride and Osilodrostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Osilodrostat can prolong the QT interval and its labeling advises caution with other QT-prolonging drugs. Together with amisulpride the risk of torsades de pointes is increased, particularly if hypokalemia develops from cortisol suppression changes.
How serious is the interaction between Amisulpride and Osilodrostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it after starting or changing doses. Correct potassium and magnesium, or use an alternative to amisulpride.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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