Drug interactions
Dronedarone + Osilodrostat
Severity: Major
Dronedarone and Osilodrostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, so combined use may increase the risk of torsades de pointes. Osilodrostat can also lower cortisol and shift electrolytes, which adds to the arrhythmic risk.
What this interaction means in plain words
Dronedarone and Osilodrostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dronedarone belongs to Cardiovascular; Osilodrostat belongs to Endocrine.
Why it happens
Additive QTc prolongation through effects on cardiac repolarization.
What to do
Avoid the combination where possible; if unavoidable, obtain a baseline ECG, correct potassium and magnesium, and repeat ECGs during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Dronedarone with Osilodrostat?
MediHelp rates the interaction as major. Dronedarone and Osilodrostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, so combined use may increase the risk of torsades de pointes. Osilodrostat can also lower cortisol and shift electrolytes, which adds to the arrhythmic risk.
How serious is the interaction between Dronedarone and Osilodrostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if unavoidable, obtain a baseline ECG, correct potassium and magnesium, and repeat ECGs during treatment.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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