Drug interactions
Atomoxetine + Peginterferon alfa 2b
Severity: Minor
Atomoxetine and Peginterferon alfa 2b: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peginterferon alfa 2b may alter CYP2D6 activity, which could change atomoxetine exposure in either direction. Any effect is expected to be small and unpredictable.
What this interaction means in plain words
Atomoxetine and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atomoxetine belongs to Central Nervous System; Peginterferon alfa 2b belongs to Anti Virals.
Why it happens
Possible interferon modulation of CYP2D6, the main atomoxetine clearance pathway; not firmly established.
What to do
Monitor heart rate, blood pressure and clinical response when interferon is started or stopped. Adjust the atomoxetine dose if adverse effects or loss of effect occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Peginterferon alfa 2b
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Peginterferon alfa 2b?
MediHelp rates the interaction as minor. Atomoxetine and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Peginterferon alfa 2b may alter CYP2D6 activity, which could change atomoxetine exposure in either direction. Any effect is expected to be small and unpredictable.
How serious is the interaction between Atomoxetine and Peginterferon alfa 2b?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and clinical response when interferon is started or stopped. Adjust the atomoxetine dose if adverse effects or loss of effect occur.
What other medicines interact with Peginterferon alfa 2b?
MediHelp also lists interactions of Peginterferon alfa 2b with, for example, Aldesleukin, Deferiprone, Pexidartinib. The full list is on the Peginterferon alfa 2b page.
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