Drug interactions
Peginterferon alfa 2b + Pretomanid
Severity: Major
Peginterferon alfa 2b and Pretomanid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The pretomanid regimen is associated with liver toxicity, and peginterferon alfa 2b may also injure the liver. Using both may raise the risk of serious hepatic adverse events.
What this interaction means in plain words
Peginterferon alfa 2b and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Peginterferon alfa 2b belongs to Anti Virals; Pretomanid belongs to Anti Bacterial.
Why it happens
Additive hepatotoxicity from two agents that can each injure the liver.
What to do
Avoid combining where possible. If unavoidable, monitor liver function regularly and interrupt therapy for significant hepatic injury.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Peginterferon alfa 2b
Other interactions of Pretomanid
Frequently asked questions
Can I take Peginterferon alfa 2b with Pretomanid?
MediHelp rates the interaction as major. Peginterferon alfa 2b and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The pretomanid regimen is associated with liver toxicity, and peginterferon alfa 2b may also injure the liver. Using both may raise the risk of serious hepatic adverse events.
How serious is the interaction between Peginterferon alfa 2b and Pretomanid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible. If unavoidable, monitor liver function regularly and interrupt therapy for significant hepatic injury.
What other medicines interact with Peginterferon alfa 2b?
MediHelp also lists interactions of Peginterferon alfa 2b with, for example, Aldesleukin, Deferiprone, Pexidartinib. The full list is on the Peginterferon alfa 2b page.
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