Drug interactions
Peginterferon alfa 2b + Pexidartinib
Severity: Major
Peginterferon alfa 2b and Pexidartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib carries a boxed warning for serious hepatotoxicity. Peginterferon alfa 2b can also cause hepatic injury, so combined use may increase the risk of liver damage.
What this interaction means in plain words
Peginterferon alfa 2b and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Peginterferon alfa 2b belongs to Anti Virals; Pexidartinib belongs to Oncology.
Why it happens
Additive hepatotoxicity from two agents that can each injure the liver.
What to do
Avoid the combination where possible. If unavoidable, check liver tests frequently and withhold either drug for significant elevations.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Peginterferon alfa 2b
Other interactions of Pexidartinib
Frequently asked questions
Can I take Peginterferon alfa 2b with Pexidartinib?
MediHelp rates the interaction as major. Peginterferon alfa 2b and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib carries a boxed warning for serious hepatotoxicity. Peginterferon alfa 2b can also cause hepatic injury, so combined use may increase the risk of liver damage.
How serious is the interaction between Peginterferon alfa 2b and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If unavoidable, check liver tests frequently and withhold either drug for significant elevations.
What other medicines interact with Peginterferon alfa 2b?
MediHelp also lists interactions of Peginterferon alfa 2b with, for example, Aldesleukin, Deferiprone, Pretomanid. The full list is on the Peginterferon alfa 2b page.
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