Drug interactions
Atomoxetine + Solifenacin
Severity: Moderate
Atomoxetine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atomoxetine can cause tachycardia and has been associated with QT prolongation in overdose or in poor metabolizers, while solifenacin may prolong QT at high doses. The combination may add modestly to arrhythmia risk in susceptible patients.
What this interaction means in plain words
Atomoxetine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atomoxetine belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Possible additive QT prolongation and heart-rate effects.
What to do
Check for other QT risk factors and consider an ECG in patients with cardiac disease. Monitor heart rate and palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Atomoxetine with Solifenacin?
MediHelp rates the interaction as moderate. Atomoxetine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atomoxetine can cause tachycardia and has been associated with QT prolongation in overdose or in poor metabolizers, while solifenacin may prolong QT at high doses. The combination may add modestly to arrhythmia risk in susceptible patients.
How serious is the interaction between Atomoxetine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check for other QT risk factors and consider an ECG in patients with cardiac disease. Monitor heart rate and palpitations.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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