Drug interactions
Atomoxetine + Vemurafenib
Severity: Major
Atomoxetine and Vemurafenib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib can prolong the QT interval in a concentration-dependent way. Atomoxetine may add to this effect, which increases the risk of ventricular arrhythmia in susceptible patients.
What this interaction means in plain words
Atomoxetine and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atomoxetine belongs to Central Nervous System; Vemurafenib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization (QT interval).
What to do
Prefer an alternative to atomoxetine where feasible. If combined, check ECG and electrolytes at baseline and periodically, and correct any abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Atomoxetine
- Atomoxetine + Isocarboxazid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Atomoxetine + Rasagiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
Other interactions of Vemurafenib
Frequently asked questions
Can I take Atomoxetine with Vemurafenib?
MediHelp rates the interaction as major. Atomoxetine and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vemurafenib can prolong the QT interval in a concentration-dependent way. Atomoxetine may add to this effect, which increases the risk of ventricular arrhythmia in susceptible patients.
How serious is the interaction between Atomoxetine and Vemurafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to atomoxetine where feasible. If combined, check ECG and electrolytes at baseline and periodically, and correct any abnormalities.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
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