Drug interactions
Atorvastatin + Bosentan
Severity: Moderate
Atorvastatin and Bosentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosentan induces CYP3A4 and can lower atorvastatin concentrations, reducing the cholesterol-lowering effect. Bosentan itself is also hepatotoxic, so liver monitoring is relevant when both are used.
What this interaction means in plain words
Atorvastatin and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Bosentan belongs to Miscellaneous.
Why it happens
Bosentan induction of CYP3A4 increases atorvastatin metabolism.
What to do
Monitor lipid levels and titrate atorvastatin to effect. Continue routine liver enzyme monitoring required for bosentan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Bosentan
- Bosentan + Cyclosporin Contraindicated
- Bosentan + Glibenclamide Contraindicated
- Bosentan + Glyburide-metformin Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Bosentan + Sparsentan Contraindicated
- Artemether / lumefantrine + Bosentan Major
Frequently asked questions
Can I take Atorvastatin with Bosentan?
MediHelp rates the interaction as moderate. Atorvastatin and Bosentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bosentan induces CYP3A4 and can lower atorvastatin concentrations, reducing the cholesterol-lowering effect. Bosentan itself is also hepatotoxic, so liver monitoring is relevant when both are used.
How serious is the interaction between Atorvastatin and Bosentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipid levels and titrate atorvastatin to effect. Continue routine liver enzyme monitoring required for bosentan.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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