Drug interactions
Atorvastatin + Cimetidine
Severity: Minor
Atorvastatin and Cimetidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine had little effect on atorvastatin exposure in studies, with only a small change in pharmacokinetics. Clinically relevant myopathy risk from this pair is low.
What this interaction means in plain words
Atorvastatin and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atorvastatin belongs to Cardiovascular; Cimetidine belongs to Gastrointestinal Tract.
Why it happens
Weak CYP3A4 inhibition by cimetidine may slightly reduce atorvastatin clearance.
What to do
No dose adjustment is required; counsel the patient to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Cimetidine?
MediHelp rates the interaction as minor. Atorvastatin and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine had little effect on atorvastatin exposure in studies, with only a small change in pharmacokinetics. Clinically relevant myopathy risk from this pair is low.
How serious is the interaction between Atorvastatin and Cimetidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; counsel the patient to report unexplained muscle pain or weakness.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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