Drug interactions
Atorvastatin + Duvelisib
Severity: Moderate
Atorvastatin and Duvelisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib is a CYP3A4 inhibitor and can raise atorvastatin exposure. This increases the risk of statin-related myopathy.
What this interaction means in plain words
Atorvastatin and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Duvelisib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated atorvastatin metabolism by duvelisib.
What to do
Monitor for muscle symptoms and consider reducing the atorvastatin dose during duvelisib therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Atorvastatin with Duvelisib?
MediHelp rates the interaction as moderate. Atorvastatin and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib is a CYP3A4 inhibitor and can raise atorvastatin exposure. This increases the risk of statin-related myopathy.
How serious is the interaction between Atorvastatin and Duvelisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and consider reducing the atorvastatin dose during duvelisib therapy.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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