Drug interactions
Atorvastatin + Fostemsavir
Severity: Moderate
Atorvastatin and Fostemsavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The active metabolite of fostemsavir inhibits OATP1B1/3 and BCRP, which may increase atorvastatin levels. Muscle toxicity risk is increased.
What this interaction means in plain words
Atorvastatin and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Fostemsavir belongs to Anti Virals.
Why it happens
Inhibition of OATP1B1/3 and BCRP transporters reduces atorvastatin uptake and efflux.
What to do
Use the lowest effective atorvastatin dose and monitor for myopathy symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Atorvastatin with Fostemsavir?
MediHelp rates the interaction as moderate. Atorvastatin and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The active metabolite of fostemsavir inhibits OATP1B1/3 and BCRP, which may increase atorvastatin levels. Muscle toxicity risk is increased.
How serious is the interaction between Atorvastatin and Fostemsavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective atorvastatin dose and monitor for myopathy symptoms.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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