Drug interactions
Atorvastatin + Imatinib
Severity: Moderate
Atorvastatin and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib is a CYP3A4 inhibitor that may raise atorvastatin exposure, which is the more relevant direction of interaction. Atorvastatin's weak P-glycoprotein inhibition is unlikely to change imatinib levels meaningfully.
What this interaction means in plain words
Atorvastatin and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Imatinib belongs to Oncology.
Why it happens
Imatinib inhibits CYP3A4, reducing atorvastatin metabolism.
What to do
Use the lowest effective atorvastatin dose and monitor for myalgia or weakness. Check creatine kinase if muscle symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Atorvastatin with Imatinib?
MediHelp rates the interaction as moderate. Atorvastatin and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib is a CYP3A4 inhibitor that may raise atorvastatin exposure, which is the more relevant direction of interaction. Atorvastatin's weak P-glycoprotein inhibition is unlikely to change imatinib levels meaningfully.
How serious is the interaction between Atorvastatin and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective atorvastatin dose and monitor for myalgia or weakness. Check creatine kinase if muscle symptoms develop.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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