Drug interactions
Atorvastatin + Lapatinib
Severity: Moderate
Atorvastatin and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits CYP3A4, P-glycoprotein and OATP1B1, and may raise atorvastatin exposure and the risk of myopathy. Atorvastatin's weak effect on lapatinib transport is of little significance.
What this interaction means in plain words
Atorvastatin and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Lapatinib belongs to Oncology.
Why it happens
Lapatinib inhibits CYP3A4 and OATP1B1, reducing atorvastatin clearance.
What to do
Use the lowest effective atorvastatin dose and counsel patients to report unexplained muscle pain. Check creatine kinase if symptoms arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Atorvastatin with Lapatinib?
MediHelp rates the interaction as moderate. Atorvastatin and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits CYP3A4, P-glycoprotein and OATP1B1, and may raise atorvastatin exposure and the risk of myopathy. Atorvastatin's weak effect on lapatinib transport is of little significance.
How serious is the interaction between Atorvastatin and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective atorvastatin dose and counsel patients to report unexplained muscle pain. Check creatine kinase if symptoms arise.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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