Drug interactions
Atorvastatin + Lemborexant
Severity: Minor
Atorvastatin and Lemborexant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atorvastatin, a weak CYP3A4 inhibitor, may modestly increase lemborexant exposure. This can increase next-day somnolence and impairment.
What this interaction means in plain words
Atorvastatin and Lemborexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atorvastatin belongs to Cardiovascular; Lemborexant belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by atorvastatin reduces lemborexant clearance.
What to do
Use the lemborexant dose recommended for weak CYP3A4 inhibitors and monitor for daytime drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Atorvastatin with Lemborexant?
MediHelp rates the interaction as minor. Atorvastatin and Lemborexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atorvastatin, a weak CYP3A4 inhibitor, may modestly increase lemborexant exposure. This can increase next-day somnolence and impairment.
How serious is the interaction between Atorvastatin and Lemborexant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lemborexant dose recommended for weak CYP3A4 inhibitors and monitor for daytime drowsiness.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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