Drug interactions
Atorvastatin + Lenacapavir
Severity: Moderate
Atorvastatin and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A4 inhibitor and may raise atorvastatin concentrations. The inhibitory effect can persist for months after the last subcutaneous dose, increasing the risk of myopathy.
What this interaction means in plain words
Atorvastatin and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Lenacapavir belongs to Anti Virals.
Why it happens
Lenacapavir inhibits CYP3A4-mediated atorvastatin metabolism.
What to do
Monitor for muscle symptoms and use the lowest effective atorvastatin dose, including after lenacapavir has been stopped. Check CK if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Atorvastatin with Lenacapavir?
MediHelp rates the interaction as moderate. Atorvastatin and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A4 inhibitor and may raise atorvastatin concentrations. The inhibitory effect can persist for months after the last subcutaneous dose, increasing the risk of myopathy.
How serious is the interaction between Atorvastatin and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and use the lowest effective atorvastatin dose, including after lenacapavir has been stopped. Check CK if symptoms develop.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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