Drug interactions
Atorvastatin + Metyrapone
Severity: Minor
Atorvastatin and Metyrapone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metyrapone is not an established OATP1B1 inhibitor and no clinically documented rise in atorvastatin exposure or myopathy exists. Metyrapone may induce CYP3A4, which could modestly lower atorvastatin levels, but this is not well characterized.
What this interaction means in plain words
Atorvastatin and Metyrapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atorvastatin belongs to Cardiovascular; Metyrapone belongs to Endocrine.
Why it happens
No established mechanism; possible weak CYP3A4 induction by metyrapone.
What to do
No routine adjustment is needed. Report unexplained muscle symptoms and review lipid response during long-term use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Metyrapone
- Metyrapone + Pacritinib Major
- Budesonide + Metyrapone Moderate
- Cortisone + Metyrapone Moderate
- Cyproheptadine + Metyrapone Moderate
- Deflazacort + Metyrapone Moderate
- Desogestrel-ethinyl estradiol + Metyrapone Moderate
Frequently asked questions
Can I take Atorvastatin with Metyrapone?
MediHelp rates the interaction as minor. Atorvastatin and Metyrapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metyrapone is not an established OATP1B1 inhibitor and no clinically documented rise in atorvastatin exposure or myopathy exists. Metyrapone may induce CYP3A4, which could modestly lower atorvastatin levels, but this is not well characterized.
How serious is the interaction between Atorvastatin and Metyrapone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Report unexplained muscle symptoms and review lipid response during long-term use.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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