Drug interactions
Atorvastatin + Mifepristone
Severity: Moderate
Atorvastatin and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may increase atorvastatin exposure, raising the risk of myopathy. The effect is greater with chronic dosing such as in Cushing's syndrome.
What this interaction means in plain words
Atorvastatin and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Mifepristone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 (and possibly OATP1B1) increases atorvastatin concentrations.
What to do
Limit the atorvastatin dose and monitor for muscle symptoms. Consider rosuvastatin or pravastatin with long-term mifepristone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Atorvastatin with Mifepristone?
MediHelp rates the interaction as moderate. Atorvastatin and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may increase atorvastatin exposure, raising the risk of myopathy. The effect is greater with chronic dosing such as in Cushing's syndrome.
How serious is the interaction between Atorvastatin and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the atorvastatin dose and monitor for muscle symptoms. Consider rosuvastatin or pravastatin with long-term mifepristone.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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