Drug interactions
Atorvastatin + Nicardipine
Severity: Minor
Atorvastatin and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine inhibits CYP3A4 and P-glycoprotein weakly to moderately, which may raise atorvastatin levels. Higher exposure increases the potential for myopathy, though clinically significant effects are uncommon.
What this interaction means in plain words
Atorvastatin and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atorvastatin belongs to Cardiovascular; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 and possibly P-glycoprotein by nicardipine reduces atorvastatin clearance.
What to do
No routine dose change is needed. Advise patients to report unexplained muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Nicardipine?
MediHelp rates the interaction as minor. Atorvastatin and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine inhibits CYP3A4 and P-glycoprotein weakly to moderately, which may raise atorvastatin levels. Higher exposure increases the potential for myopathy, though clinically significant effects are uncommon.
How serious is the interaction between Atorvastatin and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Advise patients to report unexplained muscle pain or weakness.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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