Drug interactions
Atorvastatin + Regorafenib
Severity: Moderate
Atorvastatin and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib inhibits BCRP and may increase exposure to atorvastatin, which is a BCRP substrate. This could raise the risk of statin-related muscle toxicity.
What this interaction means in plain words
Atorvastatin and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Regorafenib belongs to Oncology.
Why it happens
Regorafenib inhibits BCRP (ABCG2) and possibly OATP1B1, reducing atorvastatin efflux and clearance.
What to do
Use the lowest effective atorvastatin dose and monitor for myalgia, weakness and CK elevation. Reduce the dose or switch statins if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Regorafenib
Frequently asked questions
Can I take Atorvastatin with Regorafenib?
MediHelp rates the interaction as moderate. Atorvastatin and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regorafenib inhibits BCRP and may increase exposure to atorvastatin, which is a BCRP substrate. This could raise the risk of statin-related muscle toxicity.
How serious is the interaction between Atorvastatin and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective atorvastatin dose and monitor for myalgia, weakness and CK elevation. Reduce the dose or switch statins if symptoms occur.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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