Drug interactions
Atorvastatin + Rifapentine
Severity: Moderate
Atorvastatin and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces CYP3A4 and can lower atorvastatin concentrations. This may reduce cholesterol-lowering efficacy during tuberculosis treatment.
What this interaction means in plain words
Atorvastatin and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Rifapentine belongs to Anti Bacterial.
Why it happens
Rifapentine induces hepatic and intestinal CYP3A4, increasing atorvastatin clearance.
What to do
Monitor the lipid profile and increase the atorvastatin dose if needed. Reassess after rifapentine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Atorvastatin with Rifapentine?
MediHelp rates the interaction as moderate. Atorvastatin and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine induces CYP3A4 and can lower atorvastatin concentrations. This may reduce cholesterol-lowering efficacy during tuberculosis treatment.
How serious is the interaction between Atorvastatin and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the lipid profile and increase the atorvastatin dose if needed. Reassess after rifapentine is stopped.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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