Drug interactions
Atorvastatin + Riociguat
Severity: Minor
Atorvastatin and Riociguat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atorvastatin is not a strong CYP inhibitor and no meaningful change in riociguat exposure is expected. The legacy rationale does not describe a real interaction.
What this interaction means in plain words
Atorvastatin and Riociguat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atorvastatin belongs to Cardiovascular; Riociguat belongs to Cardiovascular.
Why it happens
No established mechanism; atorvastatin is not a significant inhibitor of the CYPs that metabolize riociguat.
What to do
No dose adjustment is needed; monitor blood pressure as usual with riociguat.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Atorvastatin with Riociguat?
MediHelp rates the interaction as minor. Atorvastatin and Riociguat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atorvastatin is not a strong CYP inhibitor and no meaningful change in riociguat exposure is expected. The legacy rationale does not describe a real interaction.
How serious is the interaction between Atorvastatin and Riociguat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor blood pressure as usual with riociguat.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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