Drug interactions
Atorvastatin + Sarecycline
Severity: Minor
Atorvastatin and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline may modestly raise atorvastatin exposure through inhibition of the efflux transporter P-glycoprotein. The clinical significance is likely small, but increased statin exposure could raise the risk of muscle adverse effects. Evidence is limited and largely in vitro.
What this interaction means in plain words
Atorvastatin and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atorvastatin belongs to Cardiovascular; Sarecycline belongs to Anti Bacterial.
Why it happens
Sarecycline may inhibit P-glycoprotein, reducing intestinal efflux of atorvastatin and increasing absorption.
What to do
No routine dose change is needed; counsel patients to report unexplained muscle pain or weakness. Consider checking creatine kinase if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Atorvastatin with Sarecycline?
MediHelp rates the interaction as minor. Atorvastatin and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline may modestly raise atorvastatin exposure through inhibition of the efflux transporter P-glycoprotein. The clinical significance is likely small, but increased statin exposure could raise the risk of muscle adverse effects. Evidence is limited and largely in vitro.
How serious is the interaction between Atorvastatin and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; counsel patients to report unexplained muscle pain or weakness. Consider checking creatine kinase if symptoms occur.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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