Drug interactions
Atorvastatin + Venetoclax
Severity: Moderate
Atorvastatin and Venetoclax: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atorvastatin may modestly increase venetoclax exposure through P-gp inhibition. Higher venetoclax levels may increase neutropenia and tumour lysis risk.
What this interaction means in plain words
Atorvastatin and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Venetoclax belongs to Miscellaneous.
Why it happens
Atorvastatin may inhibit P-glycoprotein efflux of venetoclax, although this effect is weak.
What to do
Monitor blood counts and for venetoclax toxicity. Reduce the venetoclax dose only if toxicity develops, following labeling guidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Venetoclax
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
Frequently asked questions
Can I take Atorvastatin with Venetoclax?
MediHelp rates the interaction as moderate. Atorvastatin and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atorvastatin may modestly increase venetoclax exposure through P-gp inhibition. Higher venetoclax levels may increase neutropenia and tumour lysis risk.
How serious is the interaction between Atorvastatin and Venetoclax?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for venetoclax toxicity. Reduce the venetoclax dose only if toxicity develops, following labeling guidance.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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