Drug interactions
Atorvastatin + Vinblastine
Severity: Minor
Atorvastatin and Vinblastine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vinblastine is a P-glycoprotein and CYP3A4 substrate, and atorvastatin is only a weak P-glycoprotein inhibitor. A meaningful rise in vinblastine toxicity is not well documented.
What this interaction means in plain words
Atorvastatin and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atorvastatin belongs to Cardiovascular; Vinblastine belongs to Oncology.
Why it happens
Possible weak P-glycoprotein inhibition by atorvastatin.
What to do
No dose change is needed. Monitor blood counts and neurotoxicity as part of standard vinblastine care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atorvastatin and Vinblastine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Vinblastine
Frequently asked questions
Can I take Atorvastatin with Vinblastine?
MediHelp rates the interaction as minor. Atorvastatin and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vinblastine is a P-glycoprotein and CYP3A4 substrate, and atorvastatin is only a weak P-glycoprotein inhibitor. A meaningful rise in vinblastine toxicity is not well documented.
How serious is the interaction between Atorvastatin and Vinblastine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor blood counts and neurotoxicity as part of standard vinblastine care.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
