Drug interactions
Atracurium + Carbamazepine
Severity: Minor
Atracurium and Carbamazepine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chronic carbamazepine therapy is associated with resistance to nondepolarizing neuromuscular blockers, with shorter duration of action and higher dose requirements. Atracurium is affected less than steroidal blockers but a reduced effect may occur.
What this interaction means in plain words
Atracurium and Carbamazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atracurium belongs to Musculoskeletal; Carbamazepine belongs to Central Nervous System.
Why it happens
Probable altered neuromuscular receptor sensitivity and enhanced clearance with chronic anticonvulsant use.
What to do
Monitor neuromuscular function with a nerve stimulator and give additional atracurium doses if block is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atracurium
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Atracurium with Carbamazepine?
MediHelp rates the interaction as minor. Atracurium and Carbamazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chronic carbamazepine therapy is associated with resistance to nondepolarizing neuromuscular blockers, with shorter duration of action and higher dose requirements. Atracurium is affected less than steroidal blockers but a reduced effect may occur.
How serious is the interaction between Atracurium and Carbamazepine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with a nerve stimulator and give additional atracurium doses if block is inadequate.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
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