Drug interactions
Atracurium + Clevidipine
Severity: Minor
Atracurium and Clevidipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers can modestly enhance the effect of nondepolarizing neuromuscular blockers. Clevidipine is given intravenously for a short time and any additional effect on atracurium is likely small.
What this interaction means in plain words
Atracurium and Clevidipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atracurium belongs to Musculoskeletal; Clevidipine belongs to Cardiovascular.
Why it happens
Calcium channel blockade may reduce presynaptic acetylcholine release, slightly potentiating neuromuscular blockade.
What to do
Monitor neuromuscular blockade with a train-of-four and give additional atracurium doses according to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atracurium
Other interactions of Clevidipine
Frequently asked questions
Can I take Atracurium with Clevidipine?
MediHelp rates the interaction as minor. Atracurium and Clevidipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers can modestly enhance the effect of nondepolarizing neuromuscular blockers. Clevidipine is given intravenously for a short time and any additional effect on atracurium is likely small.
How serious is the interaction between Atracurium and Clevidipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular blockade with a train-of-four and give additional atracurium doses according to response.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
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