Drug interactions
Atropine + Clozapine
Severity: Moderate
Atropine and Clozapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have strong anticholinergic activity, so combining them increases the risk of constipation, ileus, urinary retention, tachycardia, confusion and heat intolerance. Clozapine-related gastrointestinal hypomotility can be severe, so additive effects are important.
What this interaction means in plain words
Atropine and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atropine belongs to Miscellaneous; Clozapine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor bowel function, heart rate and mental status, and treat constipation promptly. Avoid unnecessary anticholinergic use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Frequently asked questions
Can I take Atropine with Clozapine?
MediHelp rates the interaction as moderate. Atropine and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have strong anticholinergic activity, so combining them increases the risk of constipation, ileus, urinary retention, tachycardia, confusion and heat intolerance. Clozapine-related gastrointestinal hypomotility can be severe, so additive effects are important.
How serious is the interaction between Atropine and Clozapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function, heart rate and mental status, and treat constipation promptly. Avoid unnecessary anticholinergic use.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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