Drug interactions
Atropine + Tolterodine
Severity: Moderate
Atropine and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block muscarinic receptors, so combined use can intensify dry mouth, constipation, urinary retention, tachycardia, blurred vision and confusion. Systemic atropine produces the greatest additive effect, and older patients are most at risk.
What this interaction means in plain words
Atropine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atropine belongs to Miscellaneous; Tolterodine belongs to Genitourinary.
Why it happens
Additive antagonism at muscarinic receptors.
What to do
Monitor heart rate, bowel and bladder function, and mental status. Avoid prolonged combined use in older patients and those with urinary retention or narrow-angle glaucoma.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atropine and Tolterodine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tolterodine
Other interactions of Atropine
- Atropine + Eluxadoline Major
- Atropine + Henbane Major
- Atropine + Pramlintide Major
- Abobotulinumtoxina + Atropine Moderate
- Aclidinium + Atropine Moderate
- Amantadine + Atropine Moderate
Frequently asked questions
Can I take Atropine with Tolterodine?
MediHelp rates the interaction as moderate. Atropine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs block muscarinic receptors, so combined use can intensify dry mouth, constipation, urinary retention, tachycardia, blurred vision and confusion. Systemic atropine produces the greatest additive effect, and older patients are most at risk.
How serious is the interaction between Atropine and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, bowel and bladder function, and mental status. Avoid prolonged combined use in older patients and those with urinary retention or narrow-angle glaucoma.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
