Drug interactions
Atropine iv / + Haloperidol
Severity: Moderate
Atropine iv / and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atropine given parenterally adds to the anticholinergic effects of haloperidol, potentially causing tachycardia, urinary retention, confusion, constipation and dry mouth. Effects are most relevant in older adults and those with delirium or glaucoma.
What this interaction means in plain words
Atropine iv / and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor heart rate, mental status and urinary and bowel function, and use the lowest effective atropine dose. Avoid in patients with narrow-angle glaucoma or significant cognitive impairment where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Atropine iv / with Haloperidol?
MediHelp rates the interaction as moderate. Atropine iv / and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atropine given parenterally adds to the anticholinergic effects of haloperidol, potentially causing tachycardia, urinary retention, confusion, constipation and dry mouth. Effects are most relevant in older adults and those with delirium or glaucoma.
How serious is the interaction between Atropine iv / and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, mental status and urinary and bowel function, and use the lowest effective atropine dose. Avoid in patients with narrow-angle glaucoma or significant cognitive impairment where possible.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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