Drug interactions
Atropine iv / + Perphenazine
Severity: Moderate
Atropine iv / and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine has anticholinergic activity, so combining it with atropine can intensify dry mouth, blurred vision, urinary retention, constipation, tachycardia and confusion. Anticholinergics may also reduce the antipsychotic's effect and, in older patients, can worsen cognition.
What this interaction means in plain words
Atropine iv / and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic pharmacodynamic effects, with anticholinergic slowing of GI motility possibly reducing oral perphenazine absorption.
What to do
Monitor for anticholinergic toxicity, especially in elderly patients and those with glaucoma, urinary retention or ileus. Use the lowest effective atropine dose and review the need for the combination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Atropine iv / with Perphenazine?
MediHelp rates the interaction as moderate. Atropine iv / and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine has anticholinergic activity, so combining it with atropine can intensify dry mouth, blurred vision, urinary retention, constipation, tachycardia and confusion. Anticholinergics may also reduce the antipsychotic's effect and, in older patients, can worsen cognition.
How serious is the interaction between Atropine iv / and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in elderly patients and those with glaucoma, urinary retention or ileus. Use the lowest effective atropine dose and review the need for the combination.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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