Drug interactions
Avapritinib + Brivaracetam
Severity: Moderate
Avapritinib and Brivaracetam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects such as drowsiness, memory impairment and confusion, and brivaracetam commonly causes somnolence and dizziness. The combination may worsen CNS adverse effects.
What this interaction means in plain words
Avapritinib and Brivaracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Brivaracetam belongs to Central Nervous System.
Why it happens
Additive CNS effects; no pharmacokinetic mechanism is established.
What to do
Monitor for cognitive changes and sedation, and advise caution with driving. Reduce or interrupt avapritinib per labeling if significant cognitive effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brivaracetam
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Brivaracetam?
MediHelp rates the interaction as moderate. Avapritinib and Brivaracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects such as drowsiness, memory impairment and confusion, and brivaracetam commonly causes somnolence and dizziness. The combination may worsen CNS adverse effects.
How serious is the interaction between Avapritinib and Brivaracetam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cognitive changes and sedation, and advise caution with driving. Reduce or interrupt avapritinib per labeling if significant cognitive effects develop.
What other medicines interact with Brivaracetam?
MediHelp also lists interactions of Brivaracetam with, for example, Benzhydrocodone / acetaminophen, Sodium oxybate, Acetaminophen / phenyltoloxamine. The full list is on the Brivaracetam page.
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