Drug interactions
Amobarbital + Avapritinib
Severity: Major
Amobarbital and Avapritinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital may induce CYP3A4 and markedly lower avapritinib exposure. This could cause loss of antitumor efficacy.
What this interaction means in plain words
Amobarbital and Avapritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Avapritinib belongs to Oncology.
Why it happens
Barbiturate induction of CYP3A4 increases avapritinib metabolism.
What to do
Avoid concomitant strong or moderate CYP3A4 inducers, as labeling recommends. Use an alternative sedative.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Amobarbital with Avapritinib?
MediHelp rates the interaction as major. Amobarbital and Avapritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital may induce CYP3A4 and markedly lower avapritinib exposure. This could cause loss of antitumor efficacy.
How serious is the interaction between Amobarbital and Avapritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant strong or moderate CYP3A4 inducers, as labeling recommends. Use an alternative sedative.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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