Drug interactions
Avapritinib + Buprenorphine
Severity: Moderate
Avapritinib and Buprenorphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, and buprenorphine causes sedation and respiratory depression. Combined use may worsen drowsiness and impaired alertness.
What this interaction means in plain words
Avapritinib and Buprenorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Buprenorphine belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for sedation and cognitive changes, and reduce the buprenorphine dose if excessive somnolence occurs. Advise against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Buprenorphine?
MediHelp rates the interaction as moderate. Avapritinib and Buprenorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects and somnolence, and buprenorphine causes sedation and respiratory depression. Combined use may worsen drowsiness and impaired alertness.
How serious is the interaction between Avapritinib and Buprenorphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and cognitive changes, and reduce the buprenorphine dose if excessive somnolence occurs. Advise against driving until the response is known.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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