Drug interactions
Avapritinib + Butorphanol
Severity: Moderate
Avapritinib and Butorphanol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects such as memory impairment, confusion and somnolence. Adding an opioid may worsen drowsiness and cognitive impairment.
What this interaction means in plain words
Avapritinib and Butorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Butorphanol belongs to Musculoskeletal.
Why it happens
Additive CNS effects; avapritinib's neurocognitive toxicity is mechanistically unclear.
What to do
Monitor cognition and sedation, and reduce the butorphanol dose if impairment appears. Follow avapritinib labelling for dose reduction if cognitive effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Butorphanol?
MediHelp rates the interaction as moderate. Avapritinib and Butorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects such as memory impairment, confusion and somnolence. Adding an opioid may worsen drowsiness and cognitive impairment.
How serious is the interaction between Avapritinib and Butorphanol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cognition and sedation, and reduce the butorphanol dose if impairment appears. Follow avapritinib labelling for dose reduction if cognitive effects develop.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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