Drug interactions
Avapritinib + Carbidopa-entacapone-levodopa
Severity: Minor
Avapritinib and Carbidopa-entacapone-levodopa: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects such as confusion and memory impairment, and levodopa can cause somnolence. Combined use may increase CNS adverse effects, though evidence is limited.
What this interaction means in plain words
Avapritinib and Carbidopa-entacapone-levodopa have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avapritinib belongs to Oncology; Carbidopa-entacapone-levodopa belongs to Central Nervous System.
Why it happens
Possible additive CNS effects; no established pharmacokinetic mechanism.
What to do
Monitor for somnolence and cognitive changes and counsel patients about driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Carbidopa-entacapone-levodopa?
MediHelp rates the interaction as minor. Avapritinib and Carbidopa-entacapone-levodopa have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Avapritinib can cause cognitive effects such as confusion and memory impairment, and levodopa can cause somnolence. Combined use may increase CNS adverse effects, though evidence is limited.
How serious is the interaction between Avapritinib and Carbidopa-entacapone-levodopa?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for somnolence and cognitive changes and counsel patients about driving.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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