Drug interactions
Avapritinib + Chlordiazepoxide
Severity: Moderate
Avapritinib and Chlordiazepoxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects such as memory impairment, confusion and somnolence. Combined with a benzodiazepine, CNS impairment may be intensified.
What this interaction means in plain words
Avapritinib and Chlordiazepoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Chlordiazepoxide belongs to Central Nervous System.
Why it happens
Additive CNS effects; avapritinib is also a weak CYP3A4 modulator, though the clinical effect on chlordiazepoxide is not established.
What to do
Monitor cognitive function and sedation; adjust or hold avapritinib per labeling if intolerable CNS effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Chlordiazepoxide?
MediHelp rates the interaction as moderate. Avapritinib and Chlordiazepoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects such as memory impairment, confusion and somnolence. Combined with a benzodiazepine, CNS impairment may be intensified.
How serious is the interaction between Avapritinib and Chlordiazepoxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cognitive function and sedation; adjust or hold avapritinib per labeling if intolerable CNS effects occur.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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