Drug interactions
Avapritinib + Doxorubicin
Severity: Minor
Avapritinib and Doxorubicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxorubicin is theorized to raise avapritinib levels via CYP3A4 inhibition, but this effect is not well established clinically. Both agents can cause cytopenias and avapritinib carries cognitive and bleeding risks.
What this interaction means in plain words
Avapritinib and Doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avapritinib belongs to Oncology; Doxorubicin belongs to Oncology.
Why it happens
Theoretical CYP3A4 inhibition by doxorubicin; not an established effect.
What to do
No empirical dose change; monitor blood counts and avapritinib adverse effects such as cognitive changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxorubicin
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Doxorubicin?
MediHelp rates the interaction as minor. Avapritinib and Doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doxorubicin is theorized to raise avapritinib levels via CYP3A4 inhibition, but this effect is not well established clinically. Both agents can cause cytopenias and avapritinib carries cognitive and bleeding risks.
How serious is the interaction between Avapritinib and Doxorubicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change; monitor blood counts and avapritinib adverse effects such as cognitive changes.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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