Drug interactions
Avapritinib + Esketamine
Severity: Moderate
Avapritinib and Esketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, which may add to the sedation and dissociation caused by esketamine. This may increase the risk of impaired alertness.
What this interaction means in plain words
Avapritinib and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Esketamine belongs to Central Nervous System.
Why it happens
Additive CNS depressant and cognitive effects.
What to do
Monitor for excessive sedation and cognitive changes during esketamine sessions. Advise patients to avoid driving or hazardous activities after dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Esketamine?
MediHelp rates the interaction as moderate. Avapritinib and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects and somnolence, which may add to the sedation and dissociation caused by esketamine. This may increase the risk of impaired alertness.
How serious is the interaction between Avapritinib and Esketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and cognitive changes during esketamine sessions. Advise patients to avoid driving or hazardous activities after dosing.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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