Drug interactions
Avapritinib + Ethosuximide
Severity: Moderate
Avapritinib and Ethosuximide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, which may add to the drowsiness caused by ethosuximide. Combined use may impair alertness and concentration.
What this interaction means in plain words
Avapritinib and Ethosuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Ethosuximide belongs to Central Nervous System.
Why it happens
Additive CNS depressant and cognitive effects.
What to do
Monitor for sedation and cognitive changes and counsel patients on driving and hazardous tasks. Reduce or withhold avapritinib per labeling if cognitive effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethosuximide
- Benzhydrocodone / acetaminophen + Ethosuximide Major
- Buprenorphine long-acting + Ethosuximide Major
- Buprenorphine subdermal implant + Ethosuximide Major
- Buprenorphine transdermal + Ethosuximide Major
- Calcium / magnesium / potassium / sodium oxybates + Ethosuximide Major
- Ethosuximide + Fentanyl intranasal Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Ethosuximide?
MediHelp rates the interaction as moderate. Avapritinib and Ethosuximide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects and somnolence, which may add to the drowsiness caused by ethosuximide. Combined use may impair alertness and concentration.
How serious is the interaction between Avapritinib and Ethosuximide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and cognitive changes and counsel patients on driving and hazardous tasks. Reduce or withhold avapritinib per labeling if cognitive effects emerge.
What other medicines interact with Ethosuximide?
MediHelp also lists interactions of Ethosuximide with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Ethosuximide page.
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