Drug interactions
Avapritinib + Gabapentin
Severity: Moderate
Avapritinib and Gabapentin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, and gabapentin is also sedating. Combined use may worsen drowsiness and cognitive impairment.
What this interaction means in plain words
Avapritinib and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Gabapentin belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects through pharmacodynamic synergism.
What to do
Monitor for cognitive changes and sedation, and reduce the gabapentin dose if needed. Counsel the patient on driving safety.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gabapentin
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Gabapentin?
MediHelp rates the interaction as moderate. Avapritinib and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects and somnolence, and gabapentin is also sedating. Combined use may worsen drowsiness and cognitive impairment.
How serious is the interaction between Avapritinib and Gabapentin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cognitive changes and sedation, and reduce the gabapentin dose if needed. Counsel the patient on driving safety.
What other medicines interact with Gabapentin?
MediHelp also lists interactions of Gabapentin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Gabapentin page.
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